Circulating 25-hydroxyvitamin D concentration and cause-specific mortality in the Melbourne Collaborative Cohort Study

AK Heath; AM Hodge; PR Ebeling; D Kvaskoff; DW Eyles; GG Giles; DR English; EJ Williamson

Journal article

Circulating 25-hydroxyvitamin D concentration and cause-specific mortality in the Melbourne Collaborative Cohort Study

AK Heath, AM Hodge, PR Ebeling, D Kvaskoff, DW Eyles, GG Giles, DR English, EJ Williamson

Journal of Steroid Biochemistry and Molecular Biology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

DOI: 10.1016/j.jsbmb.2020.105612

Abstract

Vitamin D deficiency is associated with higher all-cause mortality, but associations with specific causes of death are unclear. We investigated the association between circulating 25-hydroxyvitamin D (25(OH)D) concentration and cause-specific mortality using a case-cohort study within the Melbourne Collaborative Cohort Study (MCCS). Eligibility for the case-cohort study was restricted to participants with baseline dried blood spot samples and no pre-baseline diagnosis of cancer. These analyses included participants who died (n = 2307) during a mean follow-up of 14 years and a sex-stratified random sample of eligible cohort participants (‘subcohort’, n = 2923). Concentration of 25(OH)D was me..

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University of Melbourne Researchers

Allison Hodge Author

Graham Giles Author

Dallas English Author

Related Projects (4)

Epidemiology of chronic disease, health interventions and DNA studies

THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

Our aim is to develop appropriate infrastructures necessary to facilitate access by researchers to the accumulated data, including questionn..

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

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NON-LEAD GRANT W/ CANCER COUNCIL VIC - VITAMIN D AND RISK OF CANCER AND MORTALITY IN THE MELBOURNE COLLABORATIVE COHORT STUDY

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Grants

Awarded by VicHealth

Funding Acknowledgements

The Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by Australian National Health and Medical Research Council grants 209057, 396414 and 1074383 and by infrastructure provided by Cancer Council Victoria. This project was specifically funded by the National Health and Medical Research Council project grant 623208 (to D.R. English and D.W. Eyles).